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The Rarefied Difference

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A New Way to Think About Autoimmune Disease.

Autoimmune disease is complex. The immune system misfires, attacking the body it’s meant to protect. Existing treatments, often injections or infusions, are inconvenient. Cytokine antagonists and JAK inhibitors only partially mitigate the drivers of inflammation. B cell depletion leaves behind other inflammatory cells. Existing therapies focus downstream, and thus are inherently limited. They also compromise safety by creating risk of infections.

Rarefied Takes a Different Path

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Re-tuning autoimmune cells while leaving defenses intact

Our lead program is an oral, once-daily medicine that gently re-tunes overactive T and B cells by restoring immune regulation upstream of the inflammation that causes tissue injury. RB201 maintains healthy immune defenses, delivering durable control of autoimmunity without systemic risk.

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Our goal is to translate precise, upstream control of immune activation into meaningful therapies across a spectrum of autoimmune diseases — from rheumatoid arthritis and lupus to inflammatory bowel disease and psoriasis.

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